The Ampli1™ OncoSeek Panel for Illumina® enables the preparation of high-quality targeted NGS libraries starting from whole genome amplified DNA obtained with Ampli1 WGA Kit.
It allows the simultaneous detection of single nucleotide variants (SNVs), insertions/deletions (indels) and copy-number amplifications (CNAs) in a panel of 60 clinically relevant oncology-related genes.
The Ampli1™ OncoSeek Panel works exclusively with Ampli1™ WGA product. The complete workflow takes advantage of the isolation of 100% pure cells with the DEPArray™ system and balanced whole genome amplification using the Ampli1™ WGA kit.
Maturo et al, Cancer Genomics 2019, "Development and Validation of Target Next-Generation Sequencing Panel for detection of somatic mutations and focal Copy Number Amplifications (CNAs) in single Circulating Tumor Cells (CTCs)"
Forcato et al, EACR-ESMO Liquid Biopsies 2019, "Comprehensive molecular profiling of single Circulating Tumor Cells (CTCs) reveals intra-patient heterogeneity"
Tononi et al, AACR 2019, "Validation of a targeted sequencing workflow for sequence variants and focal Copy Number Alterations (CNAs) in single Circulating Tumor Cells (CTCs)"
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The Ampli1™OncoSeek Panel is for Research Use Only. Not for use in diagnostic procedures.